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Oxygen-free radicals are oxygen-based chemical intermediates with high reactivity, and the balance between ROS production and processes aimed at reducing ROS is referred to as the redox state [98]

[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Jung Y.J., Lee H.J., Kim J.H., Kim D.H., Kim H.K., Cho Y.-G., Bae S., Kang K.K

Unfortunately, despite providing desirable benefits in the form of transient tumor control and short-term survival, SOC does not yield meaningful improvements in long-term survival in comparison with post-surgical best supportive care, defined as symptom management (edema, nausea, pain, and malnutrition) [24, 25]

(46) conducted a study involving OVX rats exposed to CIH and treated with selective ER receptor agonists, which revealed no significant alterations in body mass

Thus, a self-reinforcing cycle is formed: ROS triggers ferroptosis and CpG release to CpG activates T cells to T cells enhance ferroptosis